New learning discoveries about 116131-44-3

116131-44-3 3-(Bromomethyl)tetrahydro-2H-pyran 22617257, aTetrahydropyrans compound, is more and more widely used in various fields.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.116131-44-3,3-(Bromomethyl)tetrahydro-2H-pyran,as a common compound, the synthetic route is as follows.

Step 1: DMPU (225ml), FeCl3(0.75g) and CuCl (0.3g) are added to 3-bromomethyltetrahydropyran (24.75g, 0.138mol), and then Et2Zn (106.8ml) is slowly dropped at 40?45 C for 45 minutes to obtain a zinc-reagent. THF (810 ml) and PdCl2(dppf) (5.09 g) are added to 4-chloro-2-(4-chlorophenyl) – thieno[2,3-d]pyridazinyl-7-ethyl formate (30g), and then addition of the zinc-reagent to the THF solution and reacted at 45C for 4 hours. The above mixture is poured into a saturated brine, filtrated after stirring for 15 minutes and placed for layer separation. The aqueous phase is extracted with THF (500 ml, 2 times). The organic phase is combined together, washed with saturated brine (500ml, 3 times) and dried with anhydrous Na2SO4 and evaporated under reduced pressure to remove solvent to obtain 4-(3-tetrahydropyranmethyl)-2-(4-chlorophenyl)-thieno[2,3-d]pyridazinyl-7-ethyl formate (25 g). MS (ESI): 417(M+1), 116131-44-3

116131-44-3 3-(Bromomethyl)tetrahydro-2H-pyran 22617257, aTetrahydropyrans compound, is more and more widely used in various fields.

Reference£º
Patent; Zhejiang Medicine Co., Ltd. Xinchang Pharmaceutical Factory; EP2241569; (2010); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics