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The present invention is directed to 6-substituted-thio-2-amino-quinoline derivatives, pharmaceutical compositions containing them and their use in the treatment of Alzheimer’s disease (AD), mild cognitive impairment, senility and / or dementia. The compounds of the present invention are inhibitors of beta- secretase, also known as beta-site amyloid cleaving enzyme, BACE, BACE1, Asp2, or memapsin2.
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Reference£º
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics