With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.185815-59-2,4-Isobutyldihydro-2H-pyran-2,6(3H)-dione,as a common compound, the synthetic route is as follows.
Example 28; One Pot Synthesis of R-CMH; To a stirred suspension of 3-isobutyl glutaric anhydride (118 mmol) and Quinidine (134 mmol) in Toluene (10 vol) at -50 C., Methanol (365 mmol) was added drop-wise. The reaction was stirred at -50 C. for 17 hours. The solution was washed with H2SO4-2N. The organic layer was filtered and extracted to NH4OH (aq.) 25% (10 vol). The aqueous solution was stirred in a closed flask at 40 C. for 24 hours and at room temperature for 48 hours. 37% HCl was added to obtain pH 3. The slurry was stirred 20 hours at room temperature and cooled to 5 C. R-CMH was filtered and dried at 55 C. under vacuum., 185815-59-2
185815-59-2 4-Isobutyldihydro-2H-pyran-2,6(3H)-dione 11480690, aTetrahydropyrans compound, is more and more widely used in various fields.
Reference£º
Patent; Hedvati, Lilach; Gilboa, Eyal; Avhar-Maydan, Sharon; US2007/293694; (2007); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics