The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.499-40-1, Name is (2R,3S,4R,5R)-2,3,4,5-Tetrahydroxy-6-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexanal, molecular formula is C12H22O11. In a Article，once mentioned of 499-40-1, Recommanded Product: 499-40-1
Simultaneous enhancements of solubility and dissolution rate of poorly water-soluble febuxostat via salts
Novel crystalline forms of febuxostat (HFEB) salts were synthesized by liquid-assisted cogrinding with 2-methylimidazole (2MI) and di-2-pyridylamine (DPA) and characterized by Hirshfeld surface analysis, IR, 1H NMR, single crystal and powder X-ray diffractions, TGA and DSC. Two new HFEB salts featured different stoichiometries: 2:1 molecular ratio in HFEB-2MI and 1:1 molecular ratio in HFEB-DPA. For HFEB-2MI salt, two HFEB molecules lost one proton forming a singly charged hydrogen carboxylate anion H(FEB)2?, which interacted with the disordered 2MI cation via the N3[sbnd]H3A?O1i (i: ?x, ?y, ?z+1) and N4[sbnd]H4B?O1ii (ii: x, y+1, z?1) hydrogen bonds to form one-dimensional structure. For HFEB-DPA salt, one proton transferred from one HFEB to DPA, which were further connected by N4[sbnd]H1?O1 and N3[sbnd]H2?O2 hydrogen bonds to form an R2 2(8) ring motif. HFEB-2MI and HFEB-DPA salts exhibited increased equilibrium solubilities and intrinsic dissolution rates compared to those of HFEB in aqueous medium.
Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.Recommanded Product: 499-40-1, you can also check out more blogs about499-40-1
Reference：
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics