If you are interested in 14215-68-0, you can contact me at any time and look forward to more communication.Application of 14215-68-0
Application of 14215-68-0, Chemistry can be defined as the study of matter and the changes it undergoes. You’ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology.14215-68-0, Name is N-((2S,3R,4R,5R,6R)-2,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-3-yl)acetamide, molecular formula is C8H15NO6. In a patent, introducing its new discovery.
Control of glycoprotein synthesis. Characterization of (1->4)-N-acetyl-beta-D-glucosaminyltransferases acting on the alpha-D-(1->3)- and alpha-D-(1->6)-linked arms of N-linked oligosaccharides
Hen oviduct membranes contain at least three N-acetyl-beta-D-glucosaminyltransferases (GlcNAc-T) that attach a betaGlcNAc residue in (1-4)-linkage to a D-Manp residue of the N-linked oligosaccharide core, i.e., (1->4)-beta-D-GlcNAc-T III which adds a “bisecting ” GlcNAc group to form the beta-D-GlcpNAc-(1->4)-beta-D-Manp-(1->4)-D-GlcNAc moiety: (1->2)-beta-D-GlcNAc-T IV which adds a GlcNAc group to the (1->3)-alpha-D-Man arm to form the beta-D-GlcpNAc-(1->4)-2)>-alpha-D-Manp-(1->3)-beta-D-Manp-(1->4)-D-GlcpNAc component; and (1->4)-beta-D-GlcNAc-T VI which adds a GlcNAc group to the alpha-D-Manp residue of beta-D-GlcpNAc-(1->6)-2)>-alpha-D-Manp-R to form beta-D-GlcpNAc-(1->6)-4)>-2)>-alpha-D-Manp-R.We now report a novel (1->4)-beta-D-GlcNAc-T activity (GlcNAc-T VI’) in hen oviduct membranes that transfers GlcNAc to beta-D-GlcpNAc-(1->2)-alpha-D-Manp-(1->6)-beta-D-Manp-R to form beta-D-GlcpNAc-(1->4)-2)>-alpha-D-Manp-(1->6)-beta-D-Manp-R.The structure of the enzyme product was confirmed by 1H NMR spectroscopy.FAB-mass spectrometry and methylation analysis.Previous work with GlcNAc-T IV was carried out with biantennary substrates; we now show that hen oviduct membrane GlcNAc-T IV can also transfer GlcNAc to monoantennary beta-D-GlcpNAc-(1->2)-alpha-D-Manp-(1->3)-beta-D-Manp-R to form beta-D-GlcpNAc-(1->4)-2)>-alpha-D-Man-p-(1->3)-beta-D-Manp-R.The findings that GlcNAc-T VI’and IV have similar kinetic characteristics and that hen oviduct membranes can convert methyl beta-D-GlcpNAc-(1->2)-alpha-D-Manp to methyl beta-D-GlcpNAc-(1->4)-2)>-alpha-D-Manp suggest that these two activities may be due to the same enzyme.The R-group of the beta-D-GlcpNAc-(1->2)-alpha-D-Manp-(1->6)-beta-D-Manp (or Glcp)-R substrate has an important influence on GlcNAc-T VI’enzyme activity.When R is GlcNAc or betaGlc-ally, the activity is drastically reduced.This may be due to conformational factors and may explain why hen oviduct membranes add a GlcNAc residue in (1->4)-beta-linkage mainly to the (1->3)-alpha-D-Man arm of the bi-antennary substrate beta-D-GlcpNAc-(1->2)-alpha-D-Manp-(1->6)-2)-alpha-D-Manp-(1->3)>-beta-D-Manp-R to form beta-D-GlcpNAc-(1->2)-alpha-D-Manp-(1->6)-2)-4)>-alpha-D-Manp-(1->3)>-beta-D-Manp-R.
If you are interested in 14215-68-0, you can contact me at any time and look forward to more communication.Application of 14215-68-0
Reference:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics