14774-36-8, (Tetrahydropyran-3-yl)methanol is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
14774-36-8, To the mixture of Compound 5 (150 mg, 0.51 mmol), DIAD (184.94 mg, 0.91 mmol) and tetrahydropyran-3-ylmethanol (106.24 mg, 0.91 mmol) in THF (5 mL) was added PPh3 (239.89 mg, 0.91 mmol). The mixture was stirred at 20 C for 16 hours under N2. The mixture was concentrated, and the residue was diluted with sat.NH4Cl (20 mL), and extracted with EtOAc (20 mL x 2). The combined organic phase was washed with brine (10 mL), dried over Na2S04 and filtered, and the filtrate was concentrated to give a residue that was purified by Prep-HPLC (Xtimate C18 (250 mm x 50mm, 10 muiotaeta) A = H20 (10 mM % NH3HCO3) and B = CH3CN); 55-85 %B over 11.3 minutes) to afford Compound 72 (52.87 mg, 0.13 mmol) as an oil. *H NMR (CD3CN 400MHz) deltaH = 7.73 (d, 2H), 7.42 – 7.35 (m, 4H), 7.33 – 7.27 (m, 1H), 3.83 – 3.69 (m, 4H), 3.43 (dt, 1H), 3.34 – 3.26 (m, 1H), 2.24 – 2.15 (m, 1H), 1.89 – 1.80 (m, 1H), 1.73 – 1.64 (m, 1H), 1.58 – 1.46 (m, 1H), 1.46 – 1.34 (m, 1H). LCMS Rt = 1.293 min using Method A, MS ESI calcd. for C20H19F3NO4 [M+H]+ 394.1, found 394.1.
The synthetic route of 14774-36-8 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; PRAXIS PRECISION MEDICINES , INC.; REDDY, Kiran; MARTINEZ BOTELLA, Gabriel; GRIFFIN, Andrew, Mark; MARRON, Brian, Edward; (244 pag.)WO2018/148745; (2018); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics