With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1194-16-7,2,2-Dimethyltetrahydropyran-4-one,as a common compound, the synthetic route is as follows.
General procedure: A mixture of equimolar amounts (0.01 mol) of carbonyl compound and 2-(2,2-dimethyl-4-propyltetrahydro-2H-pyran-4-yl)ethanamine 4 in 50 mL of benzene was boiled for 4 h with a Dean-Stark trap until the complete water liberation. The solvent was removed, the residue (0.01 mol of azomethine A) was dissolved in 40 mL of methanol and after stirring and cooling with ice water an equivalent amount of NaBH4 was added in portions so that the temperature of the reaction mixture did not exceed 20C. Then the reaction mixture was stirred for 1 h at room temperature, after distilling off the methanol the residue was alkalinized with a 20% NaOH solution. The product was extracted with benzene. The extract was dried, the solvent was distilled off, and the residue was distilled.
1194-16-7 2,2-Dimethyltetrahydropyran-4-one 1738159, aTetrahydropyrans compound, is more and more widely used in various.
Reference£º
Letter; Arutyunyan; Akopyan; Akopyan; Panosyan; Gevorgyan; Russian Journal of General Chemistry; vol. 88; 7; (2018); p. 1537 – 1541; Zh. Obshch. Khim.; vol. 88; 7; (2018); p. 1202 – 1206,5;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics