Simple exploration of 125995-03-1

125995-03-1, The synthetic route of 125995-03-1 has been constantly updated, and we look forward to future research findings.

125995-03-1, Atorvastatin lactone is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 17: (2R,4R)-1-[2-(4,6-Dihydroxytetrahydro-2-pyranyl)-ethyl]-5-(4-fluorophenyl)-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid phenylamide (18) (synthesis from Atorvastatin).; [Show Image] The atorvastatin lactone (21.6 g, 0.04 mol) was dissolved in anhydrous methylene chloride (500 ml) and then cooled to – 78 C with help of dry ice. DIBAL (80 ml, 1M solution in toluene) was added dropwise at the same temperature and stirring continued for 1 hour. The mixture was then quenched with 10 % solution of Rochelle’s salt (100 ml) and allowed to warm to room temperature. After addition of further methylene chloride (300 ml) and water (200 ml) concentrated HCl (50 ml) was added. Organic phase was separated and water phase was extracted with methylene chloride (2 x 200 ml). The combined organic phases were washed with 1 M HCl solution (2 ¡Á 100 ml), saturated NaHCO3 solution (2 ¡Á 100 ml) and brine (100 ml) and dried over anhydrous Na2SO4. Solvent was removed under reduced pressure to yield 20.6 g (95 %) of pure lactol 18. LC-MS (ESI+) m/z 543 (M+1), 507,414,388.

125995-03-1, The synthetic route of 125995-03-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Ratiopharm GmbH; EP1834944; (2007); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics