With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4677-20-7,4-(2-Bromoethyl)tetrahydropyran,as a common compound, the synthetic route is as follows.
A stirred mixture b-ketoester 7 (550 mg, 1.65 mmol), bromide 8 (335 mg, 1.73 mmol), KI (302 mg, 1.8 mmol), K2CO3 (251 mg, 1.8 mmol) and dry DMF (5 mL) was heated at 70 C for 3 h. The mixture was diluted with EtOAc (90 mL), washed with 1% aq HC1 (15 mL) and brine (15 mL), and dried over Na2S04. Removal of the solvent left a yellow oil (1.34 g) which was chromatographed on a 12 g silica cartridge, eluted with a 0 – 70% EtOAc in hexanes gradient, to give P3-001 (495 mg, 67% yield). LC-MS tR 5.41 min, m/z 446.
4677-20-7, 4677-20-7 4-(2-Bromoethyl)tetrahydropyran 22637012, aTetrahydropyrans compound, is more and more widely used in various fields.
Reference£º
Patent; UNIVERSITY OF PITTSBURGH – OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION; FOX CHASE CHEMICAL DEVELOPMENT CENTER, INC.; SMITHGALL, Thomas; REITZ, Allen; WROBEL, Jay; TICE, Colin; HAIMOWITZ, Thomas; CARLSEN, Marianne; LOUGHRAN, Marie; YE, Hong; (183 pag.)WO2020/81856; (2020); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics