85064-61-5,85064-61-5, Tetrahydropyranyl-4-acetic acid is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Example 4 1 -(4-(4-(2-((2,6-difluorobenzyl)oxy)- 1,1,1 ,3 ,3 ,3-hexafluoropropan-2-yl)phenyl)-4-((4- fluorophenyl)sulfonyl)piperidin-l-yl)-2-(tetrahydro-2H-pyran-4-yl)ethanone Hunig’s base (8.57 mu, 0.049 mmol) was added to a mixture of 4-(4-(2-((2,6- difluorobenzyl)oxy)- 1,1,1 ,3 ,3 ,3 -hexafluoropropan-2-yl)phenyl)-4-((4- fluorophenyl)sulfonyl)piperidine (10 mg, 0.016 mmol), 2-(tetrahydro-2H-pyran-4- yl)acetic acid (2.83 mg, 0.020 mmol) and (benzotriazol-1- yloxy)tris(dimethylamino)phosphonium hexafluorophosphate (8.68 mg, 0.020 mmol) in acetonitrile (0.5 mL) at room temperature. After 1 h at room temperature, LCMS analysis showed that the reaction was complete. The crude material was purified via preparative LC/MS with the following conditions: Column: Waters XBridge C18, 19 x 250 mm, 5- muiotaeta particles; Mobile Phase A: 5:95 acetonitrile: water with 10-mM ammonium acetate; Mobile Phase B: 95:5 acetonitrile: water with 10-mM ammonium acetate; Gradient: 30- 100percent B over 20 minutes, then a 5-minute hold at 100percent B; Flow: 20 mL/min. Fractions containing the desired product were combined and dried via centrifugal evaporation to give Example 4 (7.7 mg, 62percent yield). LC/MS (M+l): 738.2; LC retention time: 2.30 min (analytical HPLC Method B); IH NMR (500MHz, 1 : 1 mixture of CDCI3-CD3OD) delta ppm 7.64 (d, J=8.3 Hz, 2H), 7.47 – 7.39 (m, 3H), 7.30 – 7.22 (m, 2H), 7.06 – 6.96 (m, 4H), 4.71 (s, 2H), 4.25 (s, IH), 4.05 (d, J=13.9 Hz, IH), 3.96 – 3.85 (m, 2H), 3.46 – 3.37 (m, 2H), 3.04 (t, J=12.1 Hz, IH), 2.73 (d, J=12.2 Hz, IH), 2.67 – 2.55 (m, 2H), 2.52 – 2.24 (m, 4H), 2.06 – 1.93 (m, IH), 1.72 – 1.59 (m, 2H), 1.39 – 1.24 (m, 2H).
As the paragraph descriping shows that 85064-61-5 is playing an increasingly important role.
Reference£º
Patent; BRISTOL-MYERS SQUIBB COMPANY; DUAN, Jingwu; DHAR, T.G. Murali; JIANG, Bin; KARMAKAR, Ananta; GUPTA, Arun Kumar; LU, Zhonghui; WO2015/103510; (2015); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics