With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.29943-42-8,Dihydro-2H-pyran-4(3H)-one,as a common compound, the synthetic route is as follows.
29943-42-8, General procedure: A tetrahydrofuran solution of LHMDS (5.2 mmol) was added dropwise to a solution of the cyclic ketone (5.0 mmol) in tetrahydrofuran (20 ml) at -78 C and the resulting solution was stirred at -20 C for 1 h. The mixture was again cooled to -78 C and methyl cyanoformate (6.0 mmol) was added dropwise. After 10 min, the reaction was quenched with aqueous ammonium chloride and extracted with ether. The organic layer was washed with brine, dried (sodium sulfate) and concentrated. Column chromatography on silica gel (ether-hexane, 1:4 to 3:2) yielded the ester as an oil.
As the paragraph descriping shows that 29943-42-8 is playing an increasingly important role.
Reference£º
Article; Sengupta, Prabal; Puri, Chetan S.; Chokshi, Hemant A.; Sheth, Chetana K.; Midha, Ajay S.; Chitturi, Trinadha Rao; Thennati, Rajamannar; Murumkar, Prashant R.; Yadav, Mange Ram; European Journal of Medicinal Chemistry; vol. 46; 11; (2011); p. 5549 – 5555;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics