With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.85064-61-5,Tetrahydropyranyl-4-acetic acid,as a common compound, the synthetic route is as follows.
85064-61-5, To a solution of the compound prepared in Example 3 (183 mg) in dimethylformamide (3 mL) were added 4-tetrahydropyranylacetic acid (70 mg), 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (105 mg) and dimethylaminopyridine (155 mg) and the solution was stirred over night. After finishing the reaction, water was added to the reaction solution, which was extracted with ethyl acetate. The organic layer was washed with brine, dried over magnesium sulfate and concentrated. The obtained residue was purified by column chromatography on silica gel (methylene chloride: methanol=25:1). 4N hydrogen chloride/ethyl acetate solution was added to the reaction mixture, which was concentrated to give the compound of the present invention (79 mg) having the following physical data. TLC:Rf 0.49(chloroform:methanol=10:1); NMR (CD3OD): delta 0.98 (t, J=7.0 Hz, 3H), 1.24-1.69 (m, 8H), 1.87-2.40 (m, 7H), 2.95 (s, 3H), 3.02-3.48 (m, 6H), 3.49-3.61 (m, 2H), 3.87-3.95 (m, 2H), 4.12 (m, 1H), 4.27-4.30 (m, 2H), 7.03 (d, J=9.0 Hz, 2H), 7.06 (d, J=8.5 Hz, 2H), 7.29 (d, J=9.0 Hz, 2H), 7.49 (d, J=8.5 Hz, 2H).
85064-61-5 Tetrahydropyranyl-4-acetic acid 2773575, aTetrahydropyrans compound, is more and more widely used in various fields.
Reference£º
Patent; ONO PHARMACEUTICAL CO., LTD.; EP1604981; (2005); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics