Downstream synthetic route of 1408168-76-2

1408168-76-2 Potassium trifluoro(2-((tetrahydro-2H-pyran-2-yl)oxy)ethyl)borate 74787645, aTetrahydropyrans compound, is more and more widely used in various fields.

1408168-76-2, Potassium trifluoro(2-((tetrahydro-2H-pyran-2-yl)oxy)ethyl)borate is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A schlenk flask was charged with the compound obtained in example 1 (0.56 g, 1.3 mmol), bis(di-fe/f-butyl(4-dimethylaminophenyl)phosphine)dichloropalladium(ll) (94 mg, 0.13 mmol), potassium trifluoro(2-((tetrahydro-2/-/-pyran-2-yl)oxy)ethyl)borate (0.34 g, 1.6 mmol), and CS2CO3 (1.7 g, 5.3 mmol) and it was evacuated and backfilled with argon. Tolueneil-hO (4:1 , 10 mL) was added and the reaction mixture was heated at 100 C overnight. H2O was added and the product was extracted with EtOAc. The combined organic layers were dried over Na2S04, filtered and concentrated to dryness to give the title compound (0.62 g, Yield: 99%)., 1408168-76-2

1408168-76-2 Potassium trifluoro(2-((tetrahydro-2H-pyran-2-yl)oxy)ethyl)borate 74787645, aTetrahydropyrans compound, is more and more widely used in various fields.

Reference£º
Patent; ESTEVE PHARMACEUTICALS, S.A.; FERNANDEZ-DONIS, Ariadna; DIAZ-FERNANDEZ, Jose, Luis; ALMANSA-ROSALES, Carmen; LORENTE-CRIVILLE, Adriana; (0 pag.)WO2020/89400; (2020); A1;,
Tetrahydropyran – Wikipedia
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