With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.33024-60-1,Tetrahydro-2H-pyran-4-amine hydrochloride,as a common compound, the synthetic route is as follows.
EXAMPLE 5; Intermediate 9 (192 mg, 0.538 mmol) was combined with 4-aminotetrahydropyran hydrochloride (81. 4 mg, 0.592 mmol) and diisopropylethylamine (113 VL, 0.946 mmol) in Ti (OiPr) 4 (3.5 mL). The resulting solution was stirred overnight at room temperature. Sodium borohydride (41 mg, 1.1 mmol) and methanol (2 mL) were added and the mixture was stirred at room temperature for 30 min. Water was added and the solid was filtered off and washed with methanol. The combined filtrates were evaporated to dryness and the crude product was extracted with EA (x3) and purified by preparative TLC (10percent MeOH/DCM) to give 12.5 mg of the title compound., 33024-60-1
33024-60-1 Tetrahydro-2H-pyran-4-amine hydrochloride 44118693, aTetrahydropyrans compound, is more and more widely used in various fields.
Reference£º
Patent; MERCK & CO., INC.; WO2005/80371; (2005); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics