With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1408168-76-2,Potassium trifluoro(2-((tetrahydro-2H-pyran-2-yl)oxy)ethyl)borate,as a common compound, the synthetic route is as follows.
To a stirred solution of 2,3-dibromo-6-methoxypyridine, Step 1 : Example 31 , (1.4 g, 5.30 mmol), potassium trifluoro(2-((tetrahydro-2H-pyran-2-yl)oxy)ethyl)borate, Step 3: Example 31 , (3.7 g, 15.90 mmol) and cataCXiumA (0.35 g, 1.06 mmol) in dry 1 ,4 dioxane (12 mL), was added a solution of cesium carbonate (1.62 g, 31.80 mmol) in water (4 mL) at RT. The reaction mixture was degassed for 10 min using N2 gas. Then Pd(OAc)2 (0.33 g, 1.59 mmol) was added at RT and the reaction mixture was heated to 100 ? for 20 h. Completion of the reaction was monitored by TLC. After completion, the reaction mixture was diluted with EtOAc (10mL) and brine (10mL) and the aqueous layer was extracted with EtOAc (2 x 20 mL), washed with water (10 mL), brine (10 ml_), dried over Na2SC>4 and concentrated under reduced pressure. The resulting crude material was purified by flash chromatography using 12-15% EtOAc in petroleum ether to afford the tittle compound. Yield: 57% (1.1 g, brown gummy solid). 1H NMR (400 MHz, CDCI3): d 7.40 (d, J = 8.4 Hz, 1 H), 6.53 (d, J = 8.0 Hz, 1 H), 4.62 (d, J = 20.8 Hz, 2H), 4.20-4.11 (m, 1 H), 3.95-3.89 (m, 2H), 3.88 (s, 3H), 3.81 – 3.70 (m, 2H), 3.61-3.51 (m, 1 H), 3.50-3.46 (m, 2H), 3.07 (t, J = 7.2 Hz, 2H), 2.91 (t, J = 7.2 Hz, 2H), 1.81 (t, J = 8.4 Hz, 2H), 1.71 (t, J = 10.0 Hz, 2H), 1.62-1 .59 (m, 8H). LCMS: (Method A) 366.2 (M+H), 1.7 min, 90.1 % (Max)., 1408168-76-2
1408168-76-2 Potassium trifluoro(2-((tetrahydro-2H-pyran-2-yl)oxy)ethyl)borate 74787645, aTetrahydropyrans compound, is more and more widely used in various fields.
Reference£º
Patent; ASCENEURON S. A.; QUATTROPANI, Anna; WISHART, Grant; KULKARNI, Santosh S.; GIRI, Awadut Gajendra; RAKESH, Paul; (250 pag.)WO2020/39028; (2020); A1;,
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