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A series of alpha2-3-sialylated beta1-3-linked galactosides, including sialyl T-antigens, 3?-sialyl galacto-N-biose, 3?-sialyl lacto-N-biose, and their derivatives containing natural and non-natural sialic acid forms have been synthesized from simple monosaccharides using an efficient sequential two-step multienzyme approach.
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Reference：
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics