5631-96-9, 2-(2-Chloroethoxy)tetrahydro-2H-pyran is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
5631-96-9, (1) 15 ml of dimethylformamide, 1.06 g of 2-(tetrahydropyran-2-yl-oxy)ethyl chloride, 0.97 g of potassium carbonate and 0.1 g of potassium iodide were added to 1.30 g of 1,2,3,3a,4,5,6,7-octahydro-7-oxo-azepino[1,2,3-lm]-beta-carboline, and the mixture was stirred at 80 C. for 4 hours. After the reaction was completed, the reaction mixture was poured into ice-water and the aqueous mixture was extracted with ethyl acetat. The extract was washed with water, dried and condensed. The oily residue thus obtained was purified by silica gel chromatography (Solvent: 1% methanol-chloroform), whereby 934 mg of 1,2,3,3a,4,5,6,7-octahydro-3-[2-(tetrahydropyran-2-yl-oxy)ethyl]-7-oxo-azepino[1,2,3-lm]-beta-carboline were obtained as an oil. Yield: 47% IRnumaxfilm (cm-1): 1695, 1620, 760 Mass (m/e): 368 (M+) NMR (delta, CDCl3): 8.67-8.30 (m, 1H, aromatic); 7.73-7.13 (m, 3H, aromatic); 4.63 (broad, 1H STR34 4.83-2.52 (m, 13H); 2.50-1.00 (m, 10H)
5631-96-9 2-(2-Chloroethoxy)tetrahydro-2H-pyran 254951, aTetrahydropyrans compound, is more and more widely used in various fields.
Reference£º
Patent; Tanabe Seiyaku Co., Ltd.; US4228168; (1980); A;,
Tetrahydropyran – Wikipedia
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