344329-76-6, Tetrahydro-2H-pyran-4-carboxamide is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Example 32 A solution of Example B5 (113 mg, 0.871 mmol) in DCE (3 mL) was treated with oxalyl chloride (111 mg, 0.871 mmol), heated at 80¡ã C. for 45 min, cooled to RT, treated with a solution of DIEA (323 mg, 2.497 mmol) and Example A10 (150 mg, 0.581 mmol) in dioxane (4.50 mL) and stirred at RT for 3 h. The mixture was treated with EtOAc, washed successively with satd. NaHCO3, 1N NaOH, then brine, dried over Na2SO4, concentrated to dryness and purified via reverse-phase chromatography (MeCN/H2O with 0.1percent TFA). The organics were removed under reduced pressure and the aqueous residue was treated with satd. NaHCO3, extracted with EtOAc (3*) and the combined organics were washed with brine, dried over Na2SO4 and concentrated to dryness to afford N-((5-((2-propionamidopyridin-4-yl)oxy)pyridin-2-yl)carbamoyl)tetrahydro-2H-pyran-4-carboxamide (35 mg, 13percent). 1H NMR (400 MHz, DMSO-d6): delta 11.06 (s, 1H), 10.88 (s, 1H), 10.50 (s, 1H), 8.25 (d, J=2.9 Hz, 1H), 8.18 (d, J=5.7 Hz, 1H), 8.08 (d, J=9.0 Hz, 1H), 7.73 (dd, J=9.0, 2.9 Hz, 1H), 7.65 (d, J=2.4 Hz, 1H), 6.70 (dd, J=5.7, 2.4 Hz, 1H), 3.88 (d, J=11.3 Hz, 2H), 2.69-2.66 (m, 1H), 2.49 (m, 2H), 2.33 (q, J=7.5 Hz, 2H), 1.72 (d, J=13.1 Hz, 2H), 1.62-1.60 (m, 2H), 0.99 (t, J=7.5 Hz, 3H); MS (ESI) m/z: 414.2 (M+H+).
344329-76-6, 344329-76-6 Tetrahydro-2H-pyran-4-carboxamide 13197203, aTetrahydropyrans compound, is more and more widely used in various fields.
Reference£º
Patent; Deciphera Pharmaceuticals, LLC; Flynn, Daniel L.; Caldwell, Timothy Malcolm; Samarakoon, Thiwanka; Vogeti, Lakshminarayana; Kaufman, Michael D.; Patt, William C.; Ahn, YuMi; US2014/275016; (2014); A1;,
Tetrahydropyran – Wikipedia
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