Electric Literature of 220641-87-2, Because a catalyst decreases the height of the energy barrier, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount. 220641-87-2, Name is N-Methyltetrahydro-2H-pyran-4-amine, molecular formula is C6H13NO. In a patent, introducing its new discovery.
High-throughput screening identified a series of pyrazoloquinolines as PDE10A inhibitors. The SAR development led to the discovery of compound 27 as a potent, selective, and orally active PDE10A inhibitor. Compound 27 inhibits MK-801 induced hyperactivity at 3 mg/kg with an ED50 of 4 mg/kg and displays a ?6-fold separation between the ED50 for inhibition of MK-801 induced hyperactivity and hypolocomotion in rats.
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Reference：
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics