1228779-96-1, 3-Nitro-4-(((tetrahydro-2H-pyran-4-yl)methyl)amino)benzenesulfonamide is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Into a 8-mL round-bottom flask, was placed 4-(4- [[2-(4-chlorophenyl)-4,4-dimethylcyclohex- i-en-i – ylj methyljpiperazin- 1 -yl)-2- [ i4-thia-2,4, iO-triazatricyclo [7.5 .0.0?[3 ,7j jtetradeca- 1 (9),2,5,7- tetraen-iO-yljbenzoic acid (30 mg, 0.05 mmol, 1 equiv), 3-nitro-4-[[(oxan-4- yl)methyljaminojbenzene-i-sulfonamide (17 mg, 0.06 mmol, 1.20 equiv), EDCI (18 mg, 0.09 mmol, 2 equiv), DMAP (23 mg, 0.19 mmol, 4 equiv), DCM (3 mL). The resulting solution was stirred for overnight at room temperature. The resulting mixture was concentrated. The crude product was purified by Flash-Prep-HPLC with the following conditions (IntelFlash-i): Column, Ci8 silica gel; mobile phase, Water(0.i%FA) and ACN (48.0% ACN up to 53.0% in 7 mm, hold 95.0% in 1 mm, down to 48.0% in 1 mm within 5 ; Detector, UV 254 nm. This resulted in 10.6 mg (24.15%) of 4-(4- [[2-(4-chlorophenyl)-4,4-dimethylcyclohex- i-en-i – ylj methyljpiperazin- 1 -yl)-N-(3 -nitro-4- [[(oxan-4-yl)methylj aminoj benzenesulfonyl)-2- [1 4-thia- 2,4, iO-triazatricyclo [7.5 .0.0?[3 ,7jjtetradeca- 1 (9),2,5,7-tetraen- iO-yljbenzamide as a yellow solid. LC-MS: (ES, m/z): M+i=939, R,T= 3.55 mm. The measurements of the retention were done with a reversed phase column (C 18). Shimadzu LCMS 2020; 50*3.0 Kinetex 2.6u XB-Ci8 2.6 microm; Eluent A: water (0.05 % TFA); Eluent B: Acetonitrile; linear gradient. H-NMR:(CDC13, 300ppm): 8.7i(s, iH), 8.49 (s, iH), 7.99-7.97(m, iH), 7.8i-7.77(m, iH), 7.38-7.28(m,4H), 7.Oi-6.93(m, 2H), 6.88-6.72(m, 3H), 3.36(s, iH), 4.06-3.26(m, i8H), 2.73-2.22(m, 6H),2.i3-i.73(m, 3H), i.79-i.25(m, 6H), i.00(s, 6H)., 1228779-96-1
1228779-96-1 3-Nitro-4-(((tetrahydro-2H-pyran-4-yl)methyl)amino)benzenesulfonamide 57474953, aTetrahydropyrans compound, is more and more widely used in various fields.
Reference£º
Patent; NEWAVE PHARMACEUTICAL INC.; CHEN, Yi; LOU, Yan; (108 pag.)WO2019/40550; (2019); A1;,
Tetrahydropyran – Wikipedia
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