344329-76-6, Tetrahydro-2H-pyran-4-carboxamide is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Tetrahydro-2H-pyran-4-carbothioamide, cmpd. of formula 8 [R1=tetrahydropyran-4-yl] Tetrahydro-2H-pyran-4-carboxamide (2 g, 15.5 mmol) was suspended in dry THF (20 mL) and Lawesson’s reagent (3.13 g, 7.75 mmol) was added. After refluxing for 4 h the mixture was poured into a saturated NaHCO3 aqueous solution (200 mL) and then extracted with diethylether (4*100 mL). The organic layer was dried over Na2SO4 and evaporated to dryness, affording 1.2 g (54%) of the title compound. HPLC: Rt: min 2.79 1H NMR (401 MHz, DMSO-d6) delta ppm 9.37 (br. s., 1H), 9.08 (br. s., 1H), 3.87 (dd, J=4.0, 11.0 Hz, 2H), 3.37-3.23 (m, 2H), 2.78-2.67 (m, 1H), 1.75 (dq, J=4.5, 12.5 Hz, 2H), 1.63-1.52 (m, 2H) HRMS (ESI) calcd for C16H11NOS [M+H]+ 146.0634. found 146.0634.
344329-76-6, 344329-76-6 Tetrahydro-2H-pyran-4-carboxamide 13197203, aTetrahydropyrans compound, is more and more widely used in various fields.
Reference£º
Patent; NERVIANO MEDICAL SCIENCES S.R.L.; Pulici, Maurizio; Traquandi, Gabriella; Marchionni, Chiara; Scolaro, Alessandra; Colombo, Nicoletta; US2013/324551; (2013); A1;,
Tetrahydropyran – Wikipedia
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