125995-03-1, Atorvastatin lactone is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
The lactone (V) ( 100.0 g, 0.185 mol) was dissolved in THF (500 ml) and reacted with the suspension of calcium hydroxide ( 18.68 g, 0.185 mol) in water ( 100 ml) and stirred at 45 to 5O0C. After the reaction was over, ( 2 hrs ) the mixture was poured into water(1.0 It) and extracted twice with dichloromethane (3.0 It and 1.0 It each), the combined organic layer was washed with water( 250 ml), dried over sodium sulfate and distilled off completely to obtain a viscous residue. The residue was dissolved in methanol (500 ml), optionally treated with charcoal (5 .0 g), stirred for 30 min at 25 to 3O0C and the solution was successively filtered through hyflow and Whatman filter paper to remove the un-dissolved and suspended particles. The solvent was then distilled under vacuum as described in Example 5 to afford, after sieving through a tea filter funnel, white to off white amorphous Atorvastatin Calcium with a particle size in the range of d5o between 125 to 300 microns and d?io between 300 to 500 microns. Yield: 98.2 g (91.82%); Purity (HPLC): 99.58%; Assay (HPLC): 99.27 %; Calcium content: 3.52 %; Moisture content (by K. F):1.41 %; Residual solvents: Methanol < 0.2%, Dichloromethane <0.01%, THF <0.05%. 125995-03-1, 125995-03-1 Atorvastatin lactone 6483036, aTetrahydropyrans compound, is more and more widely used in various fields.
Reference£º
Patent; MOREPEN LABORATORIES LIMITED; WO2006/48893; (2006); A2;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics