116131-44-3, 3-(Bromomethyl)tetrahydro-2H-pyran is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To a solution of 2,4-dimethyl-N-(4-(2-oxo-1,2,3,4-tetrahydroquinolin-6-yl)thiazol-2-yl)oxazole-5-carboxamide (0.050 g, 0.136 mmol) in anhydrous dimethylformamide (3 mL) in a flamed dried flask under argon atmosphere at 0 C. was added sodium hydride (60% in mineral oil, 0.014 g, 0.339 mmol) was added in one portion. The reaction was stirred for 10 min at 0 C. then 3-(bromomethyl)tetrahydro-2H-pyran (0.024 g, 0.136 mmol) was added via syringe. The mixture was then stirred for 24 hours at room temperature. After consumption of starting material, the reaction mixture was quenched with saturated ammonium chloride (25 mL) and extracted with ethyl acetate (2*25 mL). The combined organics were washed once with saturated sodium bicarbonate (50 mL) and dried over anhydrous sodium sulfate. The concentrated residue was purified by flash chromatography over silica gel using 95:5 dichloromethane/methanol to give 2,4-dimethyl-N-(4-(2-oxo-1-((tetrahydro-2H-pyran-3-yl)methyl)-1,2,3,4-tetrahydroquinolin-6-yl)thiazol-2-yl)oxazole-5-carboxamide (0.062 g, 97%) as a white solid. 1H NMR (400 MHz, DMSO-d): delta 12.53 (s, 1H), 7.80 (m, 2H), 7.61 (s, 1H), 7.24 (d, 1H, J=8.4 Hz), 3.87 (d, 2H, J=7.2 Hz), 3.68 (m, 2H), 3.32 (m, 1H), 3.17 (dd, 1H, J=11.6, 9.6 Hz), 2.92 (m, 2H), 2.59 (m, 2H), 2.41 (s, 3H), 1.87 (m, 1H), 1.72 (m, 1H), 1.58 (m, 1H). MS (ESI): Calcd. for C24H26N4O4S: 466, found 467 (M+1)+., 116131-44-3
As the paragraph descriping shows that 116131-44-3 is playing an increasingly important role.
Reference£º
Patent; Nantbio, Inc.; Tao, Chunlin; Nallan, Laxman; Ho, David G.; Wang, Qinwei; Weingarten, Paul; Juncker-Jensen, Anna B.; (121 pag.)US2018/201610; (2018); A1;,
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