With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1240390-36-6,tert-Butyl ((3R,4R)-4-aminotetrahydro-2H-pyran-3-yl)carbamate,as a common compound, the synthetic route is as follows.
To a solution of 5,7-dichloro-3H-pyrido[3,4-d]pyridazin-4-one (100 mg) in NMP (1 ml) in a microwave tube DIPEA (0.107 ml) and ((3R,4R)-4-amino-tetrahydro-pyran-3-yl)- carbamic acid ter-butyl ester (133 mg) was added. The tube was capped and heated on a sandbath at 10000 for 3 days. After cooling to room temperature the reaction mixture was diluted with 30 ml of EtOAc and washed with brine (2 x 50 ml). Aqueaous phases were re-extracted with EtOAc (30 ml) and combined organic phases were dried and evaporated to dryness leaving a yellow solid. Purification was effected via flash chromatography.
As the paragraph descriping shows that 1240390-36-6 is playing an increasingly important role.
Reference£º
Patent; NOVARTIS AG; THOMA, Gebhard; BUEHLMAYER, Peter; VAN EIS, Maurice; SMITH, Alexander Baxter; WO2014/27300; (2014); A1;,
Tetrahydropyran – Wikipedia
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