Brief introduction of 125995-03-1

125995-03-1, As the paragraph descriping shows that 125995-03-1 is playing an increasingly important role.

125995-03-1, Atorvastatin lactone is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 3: Preparation of crystalline Form III of atorvastatin strontium salt50.0 g of atorvastatin lactone was suspended in a mixture of 200 ml of t-butyl methyl ether and 200 ml of methanol, and 3.7 g of strontium hydroxide dissolved in 200m? of water was slowly added thereto over 30 minutes, and stirred at room temperature for 3 hours. After removing the organic layer, 150 ml of t-butyl methyl ether was added to the aqueous layer, followed by stirring at room temperature for 10 minutes. The organic layer was again removed, and 50 ml of methanol, 150 ml of t-butyl methyl ether and 650 ml of distilled water were successively added to the aqueous layer. The mixture was warmed to 50 C, to which 10.2 g of strontium acetate dissolved in 250 ml of water was slowly added over 2 hours, stirred at 50 C for 17 hours, and the resulting solution was cooled to room temperature. The precipitate formed was filtered, washed with a mixture of 100 ml of methanol and 50 ml of water and dried in air, to obtain 43 g of the title compound (yield: 77%) as a white crystalline powder.Moisture content (Karl-Fisher titrator): about 5.5%The XRPD result of the crystalline powder obtained above showed that the crystalline powder is a crystal having distinctively characteristic main peaks (those having 1/I0 of at least 10%), as shown in Table 3. Accordingly, the crystalline powder is designated Form III.

125995-03-1, As the paragraph descriping shows that 125995-03-1 is playing an increasingly important role.

Reference£º
Patent; HANMI PHARM. CO., LTD.; WO2008/93951; (2008); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics