With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4677-18-3,2-(Tetrahydro-2H-pyran-4-yl)ethanol,as a common compound, the synthetic route is as follows.
To a solution of 2-(tetrahydro-2H-pyran-4-yl)ethan-l-ol (300 mg, 2.304 mmol) and TEA (0.964 mL, 6.91 mmol) in THF (10 mL) was added dropwise Ms-Cl (0.269 mL, 3.46 mmol) at 0 C. The reaction mixture was stirred for 20 hours at 25 C. The reaction mixture was poured into water (20 mL), extracted by EtOAc (30 mL), washed with 1M HC1 (5 ml), sat NaHCCh, (10 ml) and brine (10 ml). The organic layer was dried over Na2S04, filtered and concentrated to give 2-(tetrahydro-2H-pyran-4-yl)ethyl methanesulfonate (300 mg, 1.329 mmol, 57.7 % yield) as a brown oil which was used in the next step without purification.
4677-18-3, As the paragraph descriping shows that 4677-18-3 is playing an increasingly important role.
Reference£º
Patent; VIIV HEALTHCARE UK (NO.5) LIMITED; BELEMA, Makonen; EASTMAN, Kyle J.; KADOW, John F.; GILLIS, Eric P.; NAIDU, B. Narasimhulu; PARCELLA, Kyle E.; (0 pag.)WO2020/3093; (2020); A1;,
Tetrahydropyran – Wikipedia
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