Safety of (2S,3R,4R,5S,6R)-6-(Acetoxymethyl)-3-aminotetrahydro-2H-pyran-2,4,5-triyl triacetate hydrochloride, Career opportunities within science and technology are seeing unprecedented growth across the world, and those who study chemistry or another natural science at university now have increasingly better career prospects. 10034-20-5, C14H22ClNO9. A document type is Article, introducing its new discovery.
The marine sponge Microciona prolifera and human coagulation factor IX (Christmas factor)-related mono- to tri-saccharide 5-aminopentyl glycosides beta-D-Galp-R (5), beta-D-GlcpNAc-R (16), beta-D-Galp-(1->4)-beta-D-GlcpNAc-R (26), beta-D-GlcpNAc-(1->3)-beta-L-Fucp-R (39), beta-D-GlcpNAc-(1->3)-alpha-L-Fucp-R (43), beta-D-Galp-(1->4)-beta-D-GlcpNAc-(1->3)-beta-L-Fucp-R (45), and beta-D-Galp-(1->4)-beta-D-GlcpNAc-(1->3)-alpha-L-Fucp-R (47), where R is a 5-aminopentyloxy spacer moiety, which allowed the construction of glycoconjugates, were prepared.Thus 3,4,6-tri-O-acetyl-2-deoxy-2-(2,2,2-trichloroethoxycarbonylamino)-alpha-D-glucopyranosyl trichloroacetimidate (10) and 1,3,4,6-tetra-O-acetyl-2-chloroacetamido-2-deoxy-beta-D-glucopyranose (13) were condensed with N-Z-protected 5-aminopentanol (2) followed by conversion of the coupling products into the corresponding N-acetylglucosamine derivatives, to give compound 16 after deblocking.Similarly, the donors 10 and 13 were coupled to position 3 of suitably protected aminopentyl beta- (32) and alpha- (37) -L-fucopyranosides, to give the disaccharides 39 and 43, respectively.Starting from lactose, O-(2,3,4,6-tetra-O-benzoyl-beta-D-galactopyranosyl)-(1->4)-3,6-di-O-benzoyl-2-deoxy-2-(2,2,2-trichloroethoxycarbonylamino)-alpha-D-glucopyranosyl trichloroacetimidate (23) was prepared and used as an efficient disaccharide donor for the construction of ligand 26 from 2 and of the trisaccharide ligands 45 and 47 from fucosides 32 and 37, respectively.Key words: Christmas factor, human; Coagulation factor IX; Human marine sponge Microciona prolifera; Aminopentyl glycoside
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Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics