4295-99-2,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4295-99-2,4-Cyanotetrahydro-4H-pyran,as a common compound, the synthetic route is as follows.
To a stirred solution of 41 tetrahydro-2H-pyran-4-carbonitrile (100 g, 0.9 mol) in 15 ethanol (500 mL) and 18 water (500 mL) at rt, was added 44 hydroxylamine hydrochloride (144 g, 2.1 mol) followed by 105 K2CO3 (136.7 g, 1.0 mol) and the mixture was heated to 70 C. for 16 h. The mixture was cooled to rt and the solvent was removed by evaporation under reduced pressure. The residue was dissolved in 10% 183 MeOH in 68 DCM and filtered. The solvent was removed by evaporation under reduced pressure to afford the 45 title compound (91 g, 70%) as an off-white solid. 1H NMR (300 MHz, DMSO-d6) delta 1.56-1.63 (m, 4H), 2.23 (m, 1H), 3.24-3.32 (m, 2H), 3.81-3.97 (m, 2H), 5.40 (br s, 2H), 8.82 (s, 1H). [M+H]=145.3.
As the paragraph descriping shows that 4295-99-2 is playing an increasingly important role.
Reference£º
Patent; Dart NeuroScience, LLC; Bookser, Brett; Botrous, Iriny; Branstetter, Bryan; Dyck, Brian; Weinhouse, Michael; US2019/177327; (2019); A1;,
Tetrahydropyran – Wikipedia
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