1172623-99-2, tert-Butyl ((2R,3S)-2-(2,5-difluorophenyl)-5-hydroxytetrahydro-2H-pyran-3-yl)carbamate is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Oxalyl chloride (0.295g, 2.28mmol) was added to dichloromethane (20mL), the system was cooled to -70 deg.] C, dimethylsulfoxide (0.18g, 2.28mmol) was slowly added to the above solution, maintaining the temperature of the system – 70 stirring continued for 10 minutes, N-Boc- (2R, 3S) -2- (2,5- difluorophenyl) -5-hydroxy-tetrahydro -2H- pyran-3-amine (0.5g, 1.52mmol ) in dichloromethane (10 mL) was slowly added to the solution, and then slowly added triethylamine (0.46g, 4.56mmol), the resulting solution was incubated for 30 minutes, warmed to room temperature and the reaction was continued for 30 minutes and dichloromethane (30 mL ) was poured into the reaction mixture, washed with saturated sodium bicarbonate solution was added the other (20 mL), brine.The organic layer was concentrated to dryness and the residue was purified by silica gel column chromatography: to give a white solid (0.38 g, purity 97.6%, yield: 76.1%) (eluent ethyl acetate, n-hexane)., 1172623-99-2
The synthetic route of 1172623-99-2 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Shenzhen Han Yu Pharmaceutical Co., Ltd; Liu, Feipeng; Mi, Pengcheng; Tao, Anjin; Ma, Yaping; Yuan, Jiancheng; (18 pag.)CN106316888; (2017); A;,
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