1228779-96-1, 3-Nitro-4-(((tetrahydro-2H-pyran-4-yl)methyl)amino)benzenesulfonamide is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
EXAMPLE 27H4- {4-[(4′-chloro-l , 1 ‘-biphenyl-2-yl)methyl]-3-isobutylpiperazin-l -yl} -N-( {3-nitro-4- [(tetrahydro-2H-pyran-4-ylmethyl)amino]phenyl}sulfonyl)-2-phenoxybenzamide; EXAMPLE 27G (13 mg), EXAMPLE IF (7 mg), l-ethyl-3-[3- (dimethylamino)propyl]-carbodiimide hydrochloride (8 mg), and 4-dimethylaminopyridine (5 mg) were stirred in CH2Cl2 (1 mL) for 24 hours. The product was purified by preparative HPLC using a Cl 8 column, 250 x 50 mm, lOmu, and eluting with a gradient of 20-100% CH3CN vs. 0.1% trifluoroacetic aicd in water, giving the product as a trifluoroacetate salt. 1H NMR (300 MHz, dimethylsulfoxide-d6) delta 11.62 (br s, IH), 9.10 (br s, IH), 8.65 (t, IH), 8.47 (d, IH), 7.77 (dd, IH), 7.70 (br s, IH), 7.50 (m, 5H), 7.39 (m, 3H), 7.25 (m, 2H), 7.18 (d, IH), 7.01 (dd, IH), 6.83 (m, 2H), 6.76 (m, IH), 6.40 (br s, IH), 4.70 and 4.15 (both v br s, total IH), 3.85 (dd, 2H), 3.60 (v br s, IH), 3.32, 3.27, 3.24, 3.06 (all m, total 1 IH), 1.90 (m, IH), 1.62 (m, 3H), 1.30 (m, 4H), 0.70 (br m, 6H)., 1228779-96-1
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Reference£º
Patent; ABBOTT LABORATORIES; BRUNCKO, Milan; DING, Hong; DOHERTY, George, A.; ELMORE, Steven, W.; HASVOLD, Lisa; HEXAMER, Laura; KUNZER, Aaron, R.; MANTEI, Robert, A.; MCCLELLAN, William, J.; PARK, Chang, H.; PARK, Cheol-min; PETROS, Andrew, M.; SONG, Xiaohong; SOUERS, Andrew, J.; SULLIVAN, Gerard, M.; TAO, Zhi-fu; WANG, Gary, T.; WANG, Le; WANG, Xilu; WENDT, Michael, D.; WO2010/65865; (2010); A2;,
Tetrahydropyran – Wikipedia
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