So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Kriek, Nicole M. A. J.; van der Hout, Elise; Kelly, Paskal; van Meijgaarden, Krista E.; Geluk, Annemieke; Ottenhoff, Tom H. M.; van der Marel, Gijs A.; Overhand, Mark; van Boom, Jacques H.; Valentijn, A. Rob P. M.; Overkleeft, Herman S. researched the compound: tert-Butyl ((3R,6S)-6-(hydroxymethyl)tetrahydro-2H-pyran-3-yl)carbamate( cas:603130-12-7 ).Synthetic Route of C11H21NO4.They published the article 《Synthesis of novel tetrahydropyran-based dipeptide isosteres by Overman rearrangement of 2,3-didehydroglycosides》 about this compound( cas:603130-12-7 ) in European Journal of Organic Chemistry. Keywords: tetrahydropyran peptide isostere preparation Overman rearrangement dehydroglycoside; epitope Mycobacterium tuberculosis leprae peptide tetrahydropyran isostere preparation. We’ll tell you more about this compound (cas:603130-12-7).
Differently functionalized tetrahydropyran-based dipeptide isosteres have been efficiently synthesized from 3,4,6-tri-O-acetyl-D-glucal. Analogs of the hsp65 p2-13 epitope of Mycobacterium tuberculosis and Mycobacterium leprae were prepared by replacement of the Ala-Tyr or Glu-Glu moiety in the native dodecapeptide with the prepared dipeptide isosteres.
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Reference:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics