Hesp, Kevin D.; Fernando, Dilinie P.; Jiao, Wenhua; Londregan, Allyn T. published the article 《Expedient Synthesis of α-Heteroaryl Piperidines Using a Pd-Catalyzed Suzuki Cross-Coupling-Reduction Sequence》. Keywords: piperidine heteroaryl preparation; heteroaryl bromide Suzuki boronate ester reduction palladium catalyst.They researched the compound: 2-Bromo-5-methylpyrazine( cas:98006-90-7 ).Name: 2-Bromo-5-methylpyrazine. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:98006-90-7) here.
A method for the modular synthesis of α-heteroaryl piperidines is reported. The two-step procedure consists of an initial Pd-catalyzed Suzuki cross-coupling of the heteroaryl bromide with a boronate ester derived from N-Boc-piperidone, followed by subsequent tetrahydropyridine reduction Using this method, α-heteroaryl piperidine products featuring a broad range of pharmaceutically relevant azine and diazine substitutions have been prepared
If you want to learn more about this compound(2-Bromo-5-methylpyrazine)Name: 2-Bromo-5-methylpyrazine, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(98006-90-7).
Reference:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics