Name: Ethyl indoline-2-carboxylate. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: Ethyl indoline-2-carboxylate, is researched, Molecular C11H13NO2, CAS is 50501-07-0, about Synthesis and biological activity of alkyl-2-[5-(hydroxy-methyl)-5-nitro-2-oxo-1,3,2λ5-dioxaphosphinan-2-yl] amino acid esters.
Synthesis of a series of new alkyl-2-[5-(hydroxymethyl)-5-nitro-2-oxo-1,3,2λ5-dioxaphosphinan-2-yl] amino acid esters was accomplished through a two-step process. The key step in the synthesis involves preparation of a dichloride intermediate, with different amino acid esters and with a few substituted phenols by reacting POCl3 in presence of Et3N in THF at 0-15°C. In the second step the intermediate in situ is treated with tris(hydroxymethyl)nitromethane (2-hydroxymethyl-2-nitro-1,3-propanediol) in the presence of Et3N at 40-45°C to form final products. The structures of final products were established by elemental anal., IR, 1H, 13C and 31P NMR and mass spectral data. The antimicrobial activity of these compounds was evaluated and they exhibited moderate antifungal and antibacterial activities.
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Reference:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics