Flexible application of in synthetic route 50501-07-0

If you want to learn more about this compound(Ethyl indoline-2-carboxylate)Name: Ethyl indoline-2-carboxylate, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(50501-07-0).

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Asymmetric synthesis of α-amino acids. I. A new approach, published in 1970, which mentions a compound: 50501-07-0, Name is Ethyl indoline-2-carboxylate, Molecular C11H13NO2, Name: Ethyl indoline-2-carboxylate.

Asymmetric synthesis of α-amino acids from α-keto acids using chiral reagents which are regenerated by the synthesis is described. The chiral reagents used were N-amino-2-hydroxymethylindolines (I). The synthesis, resolution, and assignment of absolute configuration for these reagents is described. The application of (I) to the asymmetric synthesis of α-amino acids depends on their combination with α-keto acids to form chiral hydrazono lactones. Reduction of the C:N unit in these lactones affords the corresponding hydrazino lactones which are transformed to α-amino acids by hydrogenolysis of the N-N linkage and ester hydrolysis. By this process D-alanine and D-butyrine were synthesized from pyruvic acid and α-oxobutyric acid in optical purities of 80 and 90%, resp. A solid basis exists for the design of chiral indoline reagents of still greater efficiency in the asymmetric synthesis of α-amino acids.

If you want to learn more about this compound(Ethyl indoline-2-carboxylate)Name: Ethyl indoline-2-carboxylate, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(50501-07-0).

Reference:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics