New learning discoveries about 85064-61-5

As the paragraph descriping shows that 85064-61-5 is playing an increasingly important role.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.85064-61-5,Tetrahydropyranyl-4-acetic acid,as a common compound, the synthetic route is as follows.

85064-61-5, Oxalyl chloride (5 ml) and DMF (1 drop) were added to a solution of (TETRAHYDROPYRAN-4-YL) acetic acid (10 g) in DCM. The mixture was stirred for 3 h, then EVAPORATED IN VACUO and thoroughly azeotroped with toluene. The residue was dissolved in THF and added dropwise to a solution of (R)- BENZYLOXAZOLIDINONE (12.1 g) and nBuLi (2.5M in hexanes, 30 ml) in THF (200 ml) AT-78¡ãC. The solution was stirred for 2 h, then quenched with saturated aqueous ammonium chloride and evaporated in vacuo. The mixture was extracted with ethyl acetate, solvent washed with water and brine, dried and evaporated to give the title compound as a colourless solid (14 g). MS 304 (M + H).

As the paragraph descriping shows that 85064-61-5 is playing an increasingly important role.

Reference£º
Patent; CELLTECH R & D LIMITED; WO2004/113312; (2004); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics