The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 1-Bromo-2-pentyne(SMILESS: CCC#CCBr,cas:16400-32-1) is researched.Electric Literature of C5H8Br4. The article 《Diastereoselective synthesis of hexahydropyrrolo[2,1-a]isoquinolines by [3+2] cycloaddition and cyclative Heck alkyne hydroarylation》 in relation to this compound, is published in Tetrahedron Letters. Let’s take a look at the latest research on this compound (cas:16400-32-1).
Intermediates generated from three-component [3+2] cycloaddition of 2-bromo arylaldehydes such as 2-bromobenzaldehyde, 2-bromo-5-(trifluoromethyl)benzaldehyde, 2-bromonaphthalene-1-carbaldehyde, etc. and maleimides I (R = Me, Et, t-Bu, benzyl) with amino esters (Et 2-aminopropanoate hydrochloride) or amino acids (2-amino-2-methylpropanoic acid) underwent N-propargylation and reductive Heck cyclization to form pyrrolidinedione-fused hexahydropyrrolo[2,1-a]isoquinolines e.g., II.
There are many compounds similar to this compound(16400-32-1)Reference of 1-Bromo-2-pentyne. if you want to know more, you can check out my other articles. I hope it will help you,maybe you’ll find some useful information.
Reference:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics