So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Jones, C. David; Winter, Mark A.; Hirsch, Kenneth S.; Stamm, Nancy; Taylor, Harold M.; Holden, Howard E.; Davenport, James D.; Krumkalns, Eriks V.; Suhr, Robert G. researched the compound: 1-(Bis(4-chlorophenyl)methyl)piperazine( cas:27469-61-0 ).Related Products of 27469-61-0.They published the article 《Estrogen synthetase inhibitors. 2. Comparison of the in vitro aromatase inhibitory activity for a variety of nitrogen heterocycles substituted with diarylmethane or diarylmethanol groups》 about this compound( cas:27469-61-0 ) in Journal of Medicinal Chemistry. Keywords: heterocycle nitrogen diphenylmethyl preparation aromatase inhibition; imidazole diphenylmethyl preparation aromatase inhibitor; pyridine diphenylmethyl preparation aromatase inhibitor. We’ll tell you more about this compound (cas:27469-61-0).
The preparation and in vitro aromatase-inhibitory activity of a wide variety of heterocyclic diphenylmethane derivatives, e.g., (p-ClC4H4)2CRR1 (R = imidazolyl, pyridyl, pyrimidyl, etc.; R1 = H, HO, 1-imidazolyl), are described. Thus (p-ClC4H4)2CHCl was treated with imidazole in DMF containing NaH to give 1-[bis(p-chlorophenyl)methyl]imidazole. The choice of the 2 diaryl-bearing moieties as a vehicle for evaluating the heterocycles was made by comparing a series of imidazole- and pyridine-derived compounds with similar pyrimidine compounds reported previously. A structural model for the most active compounds is also presented. The activity of a related series of compounds containing 2 heterocyclic moieties was consistent with the model. Many of the compounds evaluated, including representatives of the pyridine, imidazole, pyrimidine, pyrazole, triazole, thiazole, and isothiazole classes, exhibit EC50 potencies for aromatase inhibition at low nanomolar levels. These compounds are at least as potent as other nonsteroidal aromatase inhibitors reported previously.
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Reference:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics