Brief introduction of 14774-36-8

14774-36-8, As the paragraph descriping shows that 14774-36-8 is playing an increasingly important role.

14774-36-8, (Tetrahydropyran-3-yl)methanol is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of (tetrahydro-2H-pyran-3-yl)methanol (1 g, 8.621 mmol, commercial source: Frapps) in Dichloromethane (20 mL), thionyl chloride (1 mL, 13.785 mmol, commercial source: Avra) was added slowly at 0 C and then stir at 26 C for 16 h. Upon completion, the reaction mixture was evaporated under reduced pressure, diluted with saturated NaHCC>3 solution (50 mL) and extracted with dichloromethane (3×50 mL).The combined organic solution was dried over anhydrous Na2S04, filtered and the filtrate was concentrated under reduced pressure to afford 3-(chloromethyl)tetrahydro-2H-pyran (300 mg).1H NMR (400 MHz, DMSO-d6) delta 3.90- 3.73 (m, 4H), 3.35-3.20 (m, 2H), 1.90-1.81 (m, 1 H), 1 .77-1 .50 (m, 2H), 1.35-1.17 (m, 2H).

14774-36-8, As the paragraph descriping shows that 14774-36-8 is playing an increasingly important role.

Reference£º
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED; ALEMPARTE-GALLARDO, Carlos; ENCINAS, Lourdes; ESQUIVIAS PROVENCIO, Jorge; (206 pag.)WO2019/34729; (2019); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics