Discovery of 16400-32-1

From this literature《Diastereoselective synthesis of hexahydropyrrolo[2,1-a]isoquinolines by [3+2] cycloaddition and cyclative Heck alkyne hydroarylation》,we know some information about this compound(16400-32-1)HPLC of Formula: 16400-32-1, but this is not all information, there are many literatures related to this compound(16400-32-1).

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 1-Bromo-2-pentyne, is researched, Molecular C5H7Br, CAS is 16400-32-1, about Diastereoselective synthesis of hexahydropyrrolo[2,1-a]isoquinolines by [3+2] cycloaddition and cyclative Heck alkyne hydroarylation.HPLC of Formula: 16400-32-1.

Intermediates generated from three-component [3+2] cycloaddition of 2-bromo arylaldehydes such as 2-bromobenzaldehyde, 2-bromo-5-(trifluoromethyl)benzaldehyde, 2-bromonaphthalene-1-carbaldehyde, etc. and maleimides I (R = Me, Et, t-Bu, benzyl) with amino esters (Et 2-aminopropanoate hydrochloride) or amino acids (2-amino-2-methylpropanoic acid) underwent N-propargylation and reductive Heck cyclization to form pyrrolidinedione-fused hexahydropyrrolo[2,1-a]isoquinolines e.g., II.

From this literature《Diastereoselective synthesis of hexahydropyrrolo[2,1-a]isoquinolines by [3+2] cycloaddition and cyclative Heck alkyne hydroarylation》,we know some information about this compound(16400-32-1)HPLC of Formula: 16400-32-1, but this is not all information, there are many literatures related to this compound(16400-32-1).

Reference:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics