With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.85064-61-5,Tetrahydropyranyl-4-acetic acid,as a common compound, the synthetic route is as follows.
85064-61-5, To the solution of 3-[1 -(azetidin-3 -ylsulfonyl)-4-piperidyl] furo [3 ,2-b]pyridine (30.0 mg, 1 equiv.), 2-tetrahydropyran-4-ylacetic acid (12.6 mg, 1.2 equiv.) and EDCxHC1 (26.8 mg, 1.5 equiv.) in DMF (0.5 mL), HOBt (21.4 mg, 1.5 equiv.) and DIPEA (47 tL, 3.0 equiv.) were added and the resulting mixture was stirred at RT. After 2 hours, reaction mixture was diluted with EtOAc (10 mL) and washed with NaHCO3 sat. solution (3 x 10 mL) andbrine (15 mL). The organic layer was dried over Na2SO4, filtered and solvent was removed in vacuo. The obtained residue was purified by preparative LC-MS (ES mode, high pH method) to afford the expected product (17.4 mg). LCMS: MW (calcd): 447.55; MS (ES, m/z): 448.2 [M+H].
85064-61-5 Tetrahydropyranyl-4-acetic acid 2773575, aTetrahydropyrans compound, is more and more widely used in various fields.
Reference£º
Patent; E-THERAPEUTICS PLC; RO?CIC, Maja; KOLUND?IC, Filip; ?IHER, Dinko; POLJAK, Tanja; VADLAMUDI, Srinivasamurthy; STUBBERFIELD, Colin; (503 pag.)WO2018/78360; (2018); A1;,
Tetrahydropyran – Wikipedia
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