In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Synthesis and hypocholesterolemic activity of some N-diphenylmethylpiperazine derivatives, published in 1991-09-30, which mentions a compound: 27469-61-0, mainly applied to diphenylmethylpiperazine preparation hypocholesterolemic; piperazine diphenylmethyl preparation hypocholesterolemic, Name: 1-(Bis(4-chlorophenyl)methyl)piperazine.
The synthesis and preliminary assays as hypocholesterolemic agents of five N-phenylmethylpiperazines I [ R = PhCC, 2-(2-thienyl)ethynyl, 2-(2-thienylvinyl); R1 = H, Cl] are described. Thus, 2-thienylacetylene was treated with 1-benphydrylpiperazine and HCHO to give 91% I (R = PhCC, R1 = Cl). The evaluations were carried out in hypercholesterolemic mice and two of these compounds were more effective than bezafibrate in the test employed. The di-p-chloro substituted compounds showed higher activity than their corresponding dechlorinated analogs.
Compound(27469-61-0)Name: 1-(Bis(4-chlorophenyl)methyl)piperazine received a lot of attention, and I have introduced some compounds in other articles, similar to this compound(1-(Bis(4-chlorophenyl)methyl)piperazine), if you are interested, you can check out my other related articles.
Reference:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics