So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Lopes, Alexandra Basilio; Wagner, Patrick; Gulea, Mihaela researched the compound: 1-Bromo-2-pentyne( cas:16400-32-1 ).Safety of 1-Bromo-2-pentyne.They published the article 《Synthesis of Benzimidazole-Fused Medium-Sized N,S-Heterocycles via Palladium-Catalyzed Cyclizations》 about this compound( cas:16400-32-1 ) in European Journal of Organic Chemistry. Keywords: homopropargyl alkylated benzimidazole palladium catalyst diastereoselective cyclocarbopalladation reduction domino; nitrogen sulfur benzimidazole fused heterocycle preparation. We’ll tell you more about this compound (cas:16400-32-1).
The synthesis of unprecedented benzimidazole-fused thiazocines, e.g., I, thiazonines, and thiazecines having an exocyclic double bond is reported. The process proceeds through an 8-, 9-, or 10-exo-dig cyclocarbopalladation followed by reduction The scope and limitations were established and showed the importance of the precursor structure for the success of the reaction. A competition between the exo-dig and the endo-dig cyclization was observed for two substrates bearing an N-homopropargyl chain, the endo-cyclization leading to rarely encountered 10- and 11-membered N,S-heterocycles with a trans-endocyclic double bond. X-ray structures of three products were obtained by co-crystallization with fumaric acid and show the twisted structures of these mols.
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Reference:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics