Simple exploration of 108-55-4

108-55-4, Dihydro-2H-pyran-2,6(3H)-dione is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 1: Preparation of 5-oxo-5-(2-oxo-4-phenyl-oxazolidin-3-yl)-pentanoic acid benzyl ester Benzyl alcohol (95.Og, 0.88mol) and sodium metal (2.01g, 0.087mol) were mixed and stirred for 30 minutes. Then, the reaction mixture was heated to 80-850C and stirred to dissolve the sodium metal. Glutaric anhydride (10Og, 0.876mol) was added and stirred for further 2 hours at 80-850C. The reaction mixture was cooled to 25-3O0C and to this dichloromethane (250ml) and demineralized water (1×25 OmI) were added. The layers were separated; organic layer was dried over sodium sulfate and concentrated at 40-450C. The reaction mixture was cooled and dichloromethane (850ml) was added. The reaction mixture was cooled to 10-150C under nitrogen atmosphere. Triethylamine (214ml, 1.535mol) was added followed by the slow addition of pivaloyl chloride (110 ml, 0.893mol). The reaction mixture was stirred at 25-3O0C for 90 minutes followed by addition of (S)-4-phenyl-2- oxazolidinone (86g, 0.527mol), N,iV-dimethyl formamide (92ml) and 4-dimethyl amino pyridine (15g, 0.123mol). The reaction mass was further refluxed for 6 hours and then cooled to 10-200C. Dilute sulphuric acid was added to the reaction mixture and stirred for 15 minutes. The layers were separated; organic layer was washed with 10% aqueous sodium bicarbonate solution (500ml) and demineralized water (500ml). The organic layer was concentrated at atmospheric pressure and finally under reduced pressure at 40-500C. Ethanol (600ml) was added to the reaction mixture and cooled to 20-300C. Title compound (1.Og) was added as seeds to the reaction mixture and stirred for 60 minutes at 20-300C. The reaction mixture was again cooled to 0-50C, stirred for 2 hours, filtered and washed with ethanol (100ml) to afford 180g of the title compound having purity 99.41% by HPLC.

108-55-4, The synthetic route of 108-55-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; IND-SWIFT LABORATORIES LIMITED; WO2009/157019; (2009); A2;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics