Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 1,3,5,7-Tetramethyl-6-phenyl-2,4,8-trioxa-6-phosphaadamantane, is researched, Molecular C16H21O3P, CAS is 97739-46-3, about Palladium-catalyzed C-O and C-C coupling reactions of electron-rich indoles.Electric Literature of C16H21O3P.
A novel palladium-catalyzed formation of indole aryl ethers is described. In general, the corresponding indole ethers are obtained in the presence of Pd(OAc)2 combined with N-phenyl-2-(di-1-adamantylphosphino)pyrrole in high yields.
In addition to the literature in the link below, there is a lot of literature about this compound(1,3,5,7-Tetramethyl-6-phenyl-2,4,8-trioxa-6-phosphaadamantane)Electric Literature of C16H21O3P, illustrating the importance and wide applicability of this compound(97739-46-3).
Reference:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics