A small discovery about 97739-46-3

In addition to the literature in the link below, there is a lot of literature about this compound(1,3,5,7-Tetramethyl-6-phenyl-2,4,8-trioxa-6-phosphaadamantane)Safety of 1,3,5,7-Tetramethyl-6-phenyl-2,4,8-trioxa-6-phosphaadamantane, illustrating the importance and wide applicability of this compound(97739-46-3).

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 1,3,5,7-Tetramethyl-6-phenyl-2,4,8-trioxa-6-phosphaadamantane( cas:97739-46-3 ) is researched.Safety of 1,3,5,7-Tetramethyl-6-phenyl-2,4,8-trioxa-6-phosphaadamantane.Le, Christine M.; Hou, Xiao; Sperger, Theresa; Schoenebeck, Franziska; Lautens, Mark published the article 《An Exclusively trans-Selective Chlorocarbamoylation of Alkynes Enabled by a Palladium/Phosphaadamantane Catalyst》 about this compound( cas:97739-46-3 ) in Angewandte Chemie, International Edition. Keywords: stereoselective synthesis chloromethyleneoxindole; oxindole chloromethylene stereoselective synthesis; palladium phosphaadamantane catalyst chlorocarbamoylation alkyne; chlorocarbamoylation; cyclization; homogenous catalysis; palladium; phosphaadamantane. Let’s learn more about this compound (cas:97739-46-3).

Pharmaceutically relevant methylene oxindoles are synthesized by a palladium(0)-catalyzed intramol. chlorocarbamoylation reaction of alkynes. A relatively underexplored class of caged phosphine ligands is uniquely suited for this transformation, enabling high levels of reactivity and exquisite trans selectivity. E.g., in presence of Pd2(dba)3 and 1,3,5,7-tetramethyl-2,4,6-trioxa-8-phenyl-6-phosphaadamantane in toluene, intramol. chlorocarbamoylation of 2-TIPSCCC6H4NBnCOCl gave 96% 3-(chloromethylene)oxindole derivative (E)-I. This report entails the first transition-metal-catalyzed atom-economic addition of a carbamoyl chloride across an alkyne.

In addition to the literature in the link below, there is a lot of literature about this compound(1,3,5,7-Tetramethyl-6-phenyl-2,4,8-trioxa-6-phosphaadamantane)Safety of 1,3,5,7-Tetramethyl-6-phenyl-2,4,8-trioxa-6-phosphaadamantane, illustrating the importance and wide applicability of this compound(97739-46-3).

Reference:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics