In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Synthesis and quantitative structure-activity relationships of antibacterial 1-(substituted benzhydryl)-4-(5-nitro-2-furfurylideneamino)piperazines, published in 1978-07-31, which mentions a compound: 27469-61-0, mainly applied to piperazine benzhydryl nitrofurfurylideneamino; bactericide benzhydrylnitrofurylideneaminopiperazine; structure activity bactericide piperazine, Safety of 1-(Bis(4-chlorophenyl)methyl)piperazine.
Twelve title compounds I (R = H, 4-Cl, 3-Me, 3,4-Cl2, etc., R1 = H, Cl, Me) were prepared by treating the corresponding benzhydryl chloride with piperazine followed by nitrosation, reduction, and condensation with 5-nitro-2-furancarboxaldehyde. I were examined for in vitro antimicrobial activity. The compounds were active against Bacillus cereus 7, Bacillus megaterium 122, Bacillus subtilis 104, Clostridium perfringens 13, and the tetracycline-resistant Clostridium perfringens 37. Regression analyses on the antibacterial activity data based on the Hansch approach, using π, π2, and σ parameters, yielded several statistically significant correlation equations. 1-Benzhydryl-4-(5-nitro-2-furfurylideneamino)piperazine stopped the protein and DNA syntheses in C. perfringens 13, as indicated by precipitable radioactivity. The compound, however, showed no effect on the cell wall synthesis in the bacteria.
This literature about this compound(27469-61-0)Safety of 1-(Bis(4-chlorophenyl)methyl)piperazinehas given us a lot of inspiration, and I hope that the research on this compound(1-(Bis(4-chlorophenyl)methyl)piperazine) can be further advanced. Maybe we can get more compounds in a similar way.
Reference:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics