So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Thadkapally, Srinivas; Farshadfar, Kaveh; Drew, Melanie A.; Richardson, Christopher; Ariafard, Alireza; Pyne, Stephen G.; Hyland, Christopher J. T. researched the compound: 1-Bromo-2-pentyne( cas:16400-32-1 ).Application of 16400-32-1.They published the article 《Rhodium-catalysed tetradehydro-Diels-Alder reactions of enediynes via a rhodium-stabilized cyclic allene》 about this compound( cas:16400-32-1 ) in Chemical Science. Keywords: isobenzofuran preparation; isoindoline preparation; indane preparation; enediyne Diels Alder reaction rhodium catalyst. We’ll tell you more about this compound (cas:16400-32-1).
Herein, tethered unconjugated enediynes R1CCCH=CHCH(R3)XCH2CCR2 [R1 = Ph, n-pentyl, 4-fluorophenyl, etc.; R2 = H, Et, Ph; R3 = H, Me, n-Pr; X = O, NTs, NNs, C(C(O)OMe)2] have been shown to undergo a facile room-temperature RhI-catalyzed intramol. tetradehydro-Diels-Alder reaction to produce highly substituted isobenzofurans, isoindolines and indane I. Furthermore, exptl. and computational studies suggest a novel mechanism involving an unprecedented and complex RhI/RhIII/RhI/RhIII redox cycle involving the formation of an unusual strained 7-membered rhodacyclic allene intermediate and a RhIII-stabilized 6-membered ring allene complex.
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Reference:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics