The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 1-Bromo-2-pentyne(SMILESS: CCC#CCBr,cas:16400-32-1) is researched.Reference of 1,3,5,7-Tetramethyl-6-phenyl-2,4,8-trioxa-6-phosphaadamantane. The article 《NHC/Nickel(II)-Catalyzed [3+2] Cross-Dimerization of Unactivated Olefins and Methylenecyclopropanes》 in relation to this compound, is published in Angewandte Chemie, International Edition. Let’s take a look at the latest research on this compound (cas:16400-32-1).
Cross-dimerization of a methylenecyclopropane and an unactivated alkene with typical hydroalkenylation reactivity was observed for the first time by using a [NHC-Ni(allyl)]BArF catalyst (NHC=N-heterocyclic carbene). Results show that the C-C cleavage of methylenecyclopropane did not involve a Ni0 oxidative addition, which was crucial in former systems. Thus the method reported here emerges as a complementary method for attaining highly chemo- and regioselective synthesis of methylenecyclopentanes with broad scope. An efficient NHC/NiII-catalyzed rearrangement of methylenecyclopropane leads to the convergent synthesis of methylenecyclopentanes in the presence of unactivated alkene.
This literature about this compound(16400-32-1)Reference of 1-Bromo-2-pentynehas given us a lot of inspiration, and I hope that the research on this compound(1-Bromo-2-pentyne) can be further advanced. Maybe we can get more compounds in a similar way.
Reference:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics