So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Feng, Tian; He, Yan; Zhang, Xinying; Fan, Xuesen researched the compound: 1-Bromo-2-pentyne( cas:16400-32-1 ).Related Products of 16400-32-1.They published the article 《Synthesis of Functionalized Cyclobutane-Fused Naphthalene Derivatives via Cascade Reactions of Allenynes with tert-Butyl Nitrite》 about this compound( cas:16400-32-1 ) in Advanced Synthesis & Catalysis. Keywords: cyclobutanol nitronaphthalenol preparation; nitrocyclobutane naphthalenedione preparation; allenyne tandem. We’ll tell you more about this compound (cas:16400-32-1).
A novel synthesis of cyclobutanol-fused 2-nitronaphthalen-1-ols I [R1 = H, 6-Cl, 7-Me, 7-OCH3; R2 = Ph, 4-ClC6H4, thiophen-3-yl, etc.] and nitrocyclobutane-fused naphthalene-1,2-diones II [R3 = H, Et, C(O)OC2H5; R4 = H, Cl, F, OCH3; R5 = H, F, OCH3, Me; R6 = H; R5R6 = -CH=CH-CH=CH-] through cascade reactions of benzene-linked allenynes 2-(CCR2)-3-(R6)-4-(R5)-5-(R4)-C6HC(O)CH=C=CHR3 with tert-Bu nitrite is presented. The formation of the title compounds I and II involves a tandem process including allenyne [2+2] cycloaddition, radical addition onto the in situ formed cyclobutenyl moiety followed by radical coupling/oxidation Interestingly, different kinds of functionalized naphthalene derivatives could be obtained selectively from the same substrates, and the selectivity was easily controlled by finely tuning the reaction conditions.
As far as I know, this compound(16400-32-1)Related Products of 16400-32-1 can be applied in many ways, which is helpful for the development of experiments. Therefore many people are doing relevant researches.
Reference:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics