With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2081-44-9,Tetrahydro-2H-pyran-4-ol,as a common compound, the synthetic route is as follows.
To a solution of tetrahydo-4-pyranol (5.00g; 48.9 mmol) in pyridine (30 mL) at 0-5 0C was added portionwise p-toluenesulfonyl chloride (13.9g; 73.4 mmol). The mixture slowly warmed to room temperature, stirred overnight and poured onto 30 mL cone. HCl in ice. After stirring 15 minutes the solid was filtered and dried in vacuo. Trituration with t-butyl methyl ether provided 11.7 g of the desired product. 1H NMR (CDCl3) delta 7.82 (d, 2H), 7.35 (d, 2H), 4.70 (m, IH), 3.88 (m, 2H), 3.47 (m, 2H), 2.46 (s, 3H), 1.86 (m, 2H), 1.76 (m, 2H)., 2081-44-9
2081-44-9 Tetrahydro-2H-pyran-4-ol 74956, aTetrahydropyrans compound, is more and more widely used in various fields.
Reference£º
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG; REGAN, John; RIETHER, Doris; WO2010/5782; (2010); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics